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Secondary measures included median absolute relative difference (ARD) and the percentage of CGM readings within 15 mg/dL of POC reference values ≤100 mg/dL or 15% of POC values >100 mg/dL (% 15/15). Mean absolute relative difference (MARD) was used as the main accuracy measure. Patients were also stratified according to renal function based on estimated glomerular filtration rate (eGFR) and severity of anemia based on hemoglobin level on admission. For assessment of accuracy during the first 12 and 24 h of sensor life, patients requiring any sensor change ( n = 61) were excluded. Matched pairs with POC glucose values outside of the CGM reading range (BG 400 mg/dL) were excluded. We matched CGM-POC glucose pairs by time, using the sensor glucose value within the following 5-min window of the POC glucose measurement to account for CGM lag time ( 17, 18).
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A total of 4,067 matched pairs of CGM and capillary POC glucose values were analyzed. POC glucose values were checked as per hospital protocol, as clinically indicated if there was a concern for hypoglycemia or if the clinical team deemed that this was necessary for patient care.
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POC BG values were obtained by hospital-calibrated Nova StatStrip ( 14) (Grady Memorial Hospital), ACCU-CHEK Inform II glucose meters ( 15) (Emory University Midtown Hospital and University of Maryland Medical Center), and Abbott Precision Xceed Pro ( 16) (Baltimore VA Medical Center). Basic demographic and inpatient clinical data were obtained from the electronic health record, and all analyzed CGM sensors had been placed on the abdomen. Patients were recruited from general medical and surgical units.